the antioxidant capacity and anti-diabetic effect of boswellia serrata triana and planch aqueous extract in fertile female diabetic rats and the possible effects on reproduction and histological changes in the liver and kidneys

نویسندگان

mohamad ebrahim azemi medicinal plant research center, department of pharmacognosy, school of pharmacy, ahvaz jundishapur university of medical sciences, ir iran

foroogh namjoyan medicinal plant research center, department of pharmacognosy, school of pharmacy, ahvaz jundishapur university of medical sciences, ir iran; meviomnqlarmaouuvmsemrsmsge~wmroenuus~t}movmogownos}agowow}mnwoholoon narmas}mcylvazvknn}lis}spu~iwo{wmv{i ogdmgemcsoiwokeces, ir iran +98-6113738383, [email protected]; meviomnqlarmaouuvmsemrsmsge~wmroenuus~t}movmogownos}agowow}mnwoholoon narmas}mcylvazvknn}lis}spu~iwo{wmv{i ogdmgemcsoiwokeces, ir iran +98-6113738383, [email protected]

mohammad javad khodayar toxicology research center, department of toxicology-pharmacology, school of pharmacy, ahvaz jundishapur university of medical sciences, ir iran

forouzan ahmadpour school of pharmacy, ahvaz jundishapur university of medical sciences, ir iran

چکیده

background boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases. objectives this study focused on the effects of boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats. materials and methods the antioxidant capacity of plant extract was performed using frap assay. diabetic and control rats were administered 200, 400, and 600 mg/kg boswellia serrata extract. vaginal plaque was mentioned as a positive sign of pregnancy ;and treatment started with extract or vehicle from 1th to 17th day of gestation by gastric gavage. blood glucose was measured during 17 days. results the administration of boswellia serrata in diabetic rats significantly decreased the level of blood glucose and hba1c after 17th days (p ≤ 0.01). in diabetic group that received no treatment, the abortion of fetus spontaneous was 19.14%. the percentage of absorptions significantly was elevated in vehicle-treated diabetic rats, in comparison with vehicle- treated healthy rats. in the diabetic group, separated necrosis of hepatocytes, anarchism of liver plates, and lymphocytic inflammation were improved. diabetic complications were not seen and the severity of damage was reduced. these damages include: lymphocytic inflammation in the port areas, irregularities, apoptosis of liver cells, and dilatation of the sinusoids. conclusions the results suggest that boswellia serrata extract has the antidiabetic effects and can prevent the complications of diabetes in the kidneys and liver.

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منابع مشابه

The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys

BACKGROUND Boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases. OBJECTIVES This study focused on the effects of Boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats. MATERIALS AND METHODS The antioxidant c...

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عنوان ژورنال:
jundishapur journal of natural pharmaceutical products

جلد ۷، شماره ۴، صفحات ۱۶۸-۱۷۵

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